Senior Biomedical Research Scientist

2 weeks ago

Beijing, Beijing, China Novo Nordisk Full time

Novo Nordisk Research Centre China

Location: Chaoyang District, Beijing

Open Rank Scientist in Discovery Screening Department, Discovery Biology China (DBC) unit

Novo Nordisk is a global healthcare company and a world leader in diabetes and obesity care. Our purpose is to drive changes to defeat diabetes, obesity, and other serious chronic diseases such as NASH, CVD, CKD, rare blood and rare endocrine diseases. We do so by pioneering scientific breakthroughs, expanding access to our medicines, and working to prevent and ultimately cure the diseases we treat. Novo Nordisk Research Centre China (NNRCC) is an integrated part of Novo Nordisk R&D organization, offering an exciting opportunity to be part of our mission-driven team.

We are seeking an exceptional, self-motivated scientist with experience and expertise in identifying and validating novel therapeutic targets for the treatment of chronic metabolic diseases. Using in vitro disease models coupled with forward and reverse screens, you will play a key role in investigating the functions of targets and validating their potential in therapeutic intervention to address unmet medical needs. Working cross-functionally within Novo Nordisk, you will oversee the progression of early proof of concepts for preclinical targets.

Key Responsibilities


• Independently develop, optimize, and validate in vitro cell-based assays related to metabolic diseases.


• Lead collaborative efforts with internal and external partners focused on target validation for metabolic disease treatment.


• Oversee, maintain, and continuously improve the infrastructure and workflow of target identification and validation.


• Contribute to global R&D projects and pipeline.


• Network and establish collaborations with external partners.


• Develop innovative technologies to solve unmet medical needs.

Requirements


• PhD in cell biology, molecular biology, or related disciplines with education or working experience.


• Deep understanding of the molecular/cellular basis of obesity and T2D, including eating behaviour, energy expenditure, mitochondria biology, and insulin resistance.


• Experience in developing monocellular and multicellular 2D and 3D cell cultures, such as hepatocytes, adipocytes, skeletal muscle cells, or neurons.


• Experience with gene perturbation tools, such as CRISPR-Cas9 and RNAi screens, is required.


• Experience in multi-omics data generation, AI/machine-learning aided integrative analysis, and interpretation is a strong plus.


• Superior knowledge of preventative and therapeutic developmental and clinical testing landscapes/pipelines for metabolic diseases is a strong plus.


• Excellent problem-solving skills and track record of driving changes.


• Ability to work independently and in a team-oriented environment.


• Ability to network, expand influence, and achieve success in a globalized research setting.


• High degree of self-motivation and ability to manage multiple competing responsibilities.


• Outstanding verbal and written communication skills in English.


• Solid organization and time management skills.

We commit to an inclusive recruitment process and equality of opportunity for all our job applicants.

Novo Nordisk recognizes that a diverse and inclusive work environment is essential for innovation and success. We strive to create a culture that celebrates diversity, promotes equality, and fosters a sense of belonging among our employees, patients, and communities. Together, we're life-changing.

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