Pharmacology Director药理总监

5 days ago

Shanghai, Shanghai, China Sironax Full time CN¥900,000 - CN¥1,200,000 per year

Role/Function Summary:

职位/职能概述:

Pharmacology director will be responsible for driving projects from early target discovery through to IND submission and supporting the translational research for related clinical stage projects. This role will possess a deep scientific background in CNS diseases, a proven track record of leading successful drug discovery programs, and exceptional team leadership abilities.

药理总监职位将负责推动项目从早期靶点发现到新药临床研究申报,并支持相关临床项目的转化医学研究。该岗位人员具备深厚的中枢神经系统疾病科学背景、成功领导药物研发项目的过往记录,以及卓越的团队领导能力。

Project Leadership & Advancement

项目领导与推进

  • Lead the integration of in vitro and in vivo pharmacology strategies to validate novel targets, screen and optimize lead molecules, and elucidate mechanisms of action.

领导体外和体内药理学的整合战略,以验证新靶点、筛选和优化先导分子,并阐明药物作用机制。

  • Serve as the project leader or key scientific driver for CNS programs, ensuring timely progression and effective risk management. Define project scope, goals and critical decision points.
  • 担任中枢神经系统项目的项目负责人或关键科学推动者,确保项目及时推进并进行有效的风险管理, 界定项目范围、目标和关键决策点。
  • Oversee and direct the preparation of the pharmacology sections for IND applications, ensuring all data packages are robust, compliant, and submission-ready.
  • 监督并指导新药临床研究申报中药理学部分的资料准备,确保所有数据包稳健、合规并符合申报要求。

Scientific & Technical Excellence

科学与技术卓越 |

  • Drive the establishment and validation of innovative and physiologically relevant in vitro and in vivo models for CNS disorders (e.g., neurodegenerative, neuropsychiatric, neuroinflammatory diseases).
  • 推动针对中枢神经系统疾病(如神经退行性疾病、神经精神疾病、神经炎症疾病)创新且具有生理相关性的体外和体内模型的建立与验证。
  • Ensure the generation of high-quality, reproducible data to establish strong PK/PD relationships and proof-of-concept for drug candidates.
  • 确保生成高质量、可重复的数据,以建立清晰的药代/药效关系并为候选药物提供概念验证。
  • Stay at the forefront of CNS research, incorporating new scientific insights and technological advancements into the R&D strategy.
  • 站在中枢神经系统研究的前沿,将新的科学见解和技术进步融入研发战略。

Cross-functional Collaboration

跨职能协作

  • Work closely with cross-functional (Protein Science, Medicinal Chemistry, DMPK, Toxicology, Clinical Development) to ensure seamless integration and execution of project goals.
  • 与其他部门人员(蛋白科学、药物化学、药代动力学、毒理学、临床开发)紧密合作,确保项目目标的无缝整合与执行。
  • Effectively communicate complex scientific rationale, study results, and project recommendations to senior management
  • 向高级管理层有效沟通复杂的科学原理、研究结果和项目建议。
  • Oversee the scientific collaboration with external CROs and academic collaborators

监督与外部CRO或者学术合作者的科研合作。

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