Senior/Executive Director, Biologics

4 days ago

Shanghai, Shanghai, China Sironax Full time CN¥120,000 - CN¥180,000 per year

Position Summary

We are seeking an accomplished leader to join our team as
Senior/Executive Director of Antibody Development
. This role will own the end-to-end design and build-out of our antibody-based brain delivery platforms and derivative therapeutics. The ideal candidate shall have comprehensive expertise in the full biologics development lifecycle, from target receptor selection, binder discovery, through biologics engineering, small-scale manufacturing, in-vitro/in-vivo validation, and IND-enabling translation, with a focus on crossing the blood-brain barrier (BBB) and creating multi-modal conjugates.

Key Responsibilities

  • Lead and oversee all aspects of antibody development programs, from
    target identification, validation, and antibody discovery
    through
    preclinical and clinical studies
    .
  • Define scientific strategy and guide cross-functional teams in antibody engineering, optimization, pharmacology, and translational development.
  • Partner with research, clinical, and regulatory teams to ensure seamless advancement of programs through development milestones.
  • Have deep knowledge of the following know-hows
  • Discovery & engineering
  • Antigen design.
  • Binder discovery through various platforms
  • Bi/Multi-Specific biologics creation and optimization
  • Manufacture & analytics
  • Transient/stable expression (HEK/CHO), Protein A and orthogonal purification; analytical panel: SEC-MALS, CE-SDS, icIEF, DSC/DSF, SPR/BLI, endotoxin, sub-visible particles, etc.
  • Early formulation screens; stress/stability/liquid-high-concentration risk assessment.
  • Pharmacology and translation
  • Target validation and biomarker development
  • In vitro and in vivo antibody profiling
  • PK/PD study design and modeling
  • CMC/Reg/Nonclinical integration; author sections of IND/IMPD

Preferred Qualifications

  • Experience with
    CNS targets
    and an understanding of the unique challenges of developing biologics for neurological indications.
  • Knowledge of
    blood-brain barrier (BBB) biology
    and strategies for enhancing antibody delivery across the BBB.
  • Experience with development of
    brain delivery technologies
    (antibody, peptide etc.)
  • Experience with
    antibody-oligo
    (ASO, siRNA etc.) development. Publications or patents in BBB-crossing technologies or multi-specific biologics.
  • Familiarity with regulatory requirements for IND-enabling studies.

Qualifications

  • Ph.D., (or equivalent) in Immunology, Molecular Biology, Biochemistry, or a related field.
  • Extensive experience (8+ years)
    in antibody drug discovery and development, including leadership of programs through IND submission and clinical studies.
  • Proven ability to lead multidisciplinary teams and manage complex projects at the interface of research and clinical development.
  • Strong knowledge of antibody engineering, therapeutic antibody modalities, and translational development pathways.
  • Demonstrated success in advancing programs from
    concept to clinic
    .
  • Domain Knowledge
    : Understanding of neurodegenerative diseases, neuroinflammation, and aging biology. Familiarity with modalities like oligos and peptides for CNS delivery.
  • Soft Skills
    : Excellent problem-solving, project management, and communication abilities. Ability to thrive in a fast-paced, collaborative environment.

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