Open Rank Scientist-Metabolic Disease cell based assay

3 months ago

Beijing, China Novo Nordisk AS Full time

Novo Nordisk Research Centre China

Location: Chaoyang District, Beijing

Open rank Scientist in Discovery Screening Department, Discovery Biology China (DBC) unit

Novo Nordisk is a global healthcare company and a world leader in diabetes and obesity care. Our purpose is to drive changes to defeat diabetes, obesity, and other serious chronic diseases such as NASH, CVD, CKD, rare blood and rare endocrine diseases. We do so by pioneering scientific breakthroughs, expanding access to our medicines, and working to prevent and ultimately cure the diseases we treat. Novo Nordisk Research Centre China (NNRCC) is an integrated part of Novo Nordisk R&D organization, this position affords the exciting opportunity to join our team to fulfill this mission.

We are seeking an exceptional, self-motivated scientist who is passionate about this mission and has expertise and experience in identification and validation of novel therapeutic targets for the treatment of chronic metabolic disease.

Using in vitro disease models coupled with forward and reverse screens, you will play a key role to investigate the functions of targets and validate their potential in therapeutic intervention to address unmet medical needs. Working cross-functionally within Novo Nordisk, you will oversee the progression of early proof of concepts for preclinical targets.

Opportunities

• Independently develop, optimize, and validate in vitro cell based assays that are related to metabolic diseases.
• Lead collaborative efforts with internal and external partners focused on the validation of targets for the treatment of metabolic diseases.
• Oversee, maintain, and continuously improve the infrastructure and workflow of target identification and validation.
• Contribute to the global R&D projects and pipeline.
• Network and establish collaboration with external partners.
• Develop innovative technologies to solve unmet medical needs.

Qualifications

• PhD in cell biology, molecular biology or related disciplines with education or working experience.
• Deep understanding of the molecular/cellular basis of obesity and T2D, e.g., energy expenditure, mitochondria function, FA beta-oxidation, futile cycling, insulin resistance.
• Experience in developing monocellular and multicellular 2D or 3D cell cultures such as hepatocytes, adipocytes, skeletal muscle cells or neurons is required.
• Experience with gene perturbation tools, such as CRISPR-Cas9 and RNAi screens is required.
• Superior knowledge of the current preventative and therapeutic developmental and clinical testing landscapes/pipelines about metabolic diseases is a strong plus.
• Experience in AI/machine-learning aided multi-layer data integrative analysis and interpretation is a strong plus.
• Excellent problem-solving skills and track record of driving changes.
• Demonstrated ability to work independently and in a team-oriented environment.
• Ability to network, expand influence, and achieve success in a globalized research setting.
• Be able to manage multiple competing responsibilities with a high degree of self-motivation.
• Outstanding verbal and written communication skills in English.
• Solid organization and time management skills.

We commit to an inclusive recruitment process and equality of opportunity for all our job applicants. 

At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.

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