Senior Scientist, Computer-Aided Drug Design
6 months ago
The Position
Primary Purpose of Job
As a member of the AI, Data and Digital (AIDD) team, you will partner with research scientists and data experts at China Innovation Center of Roche (CICoR) on drug projects from target identification to lead discovery and early development. You will employ a combination of various capabilities including computational chemistry and cheminformatics skills, AI technologies, and molecular science knowledge to provide timely compound design and data analysis to contribute to drug projects.
Responsibilities:
Apply computational chemistry techniques to advance small-molecule drug discovery programs (Work collaboratively with chemists, biologists and multidisciplinary project team members from target assessment to hit identification, compound optimization towards clinical candidates) A key contributor to compound design and optimization from molecular modeling and data analysis viewpoints (Devise and implement testable hypotheses to formulate compound design strategies) Help with new target assessment through druggability, selectivity and/or tool compound analysis. Generate knowledge and insights at the molecular level and help to assist biophysics and biochemical assay interpretation Conduct scientific method development in specific cheminformatics/AI (virtual screening, model building for on-target potency or property prediction, molecule generation, etc.) or molecular modeling (SBDD or binding free energy calculation) areas applicable to drug discovery Apply existing machine learning or deep learning models in projects, or further develop better algorithm partnering with AI researchers if appropriate Have the opportunity to lead CADD initiatives or projectsRequirements:
Ph. D in Computational Chemistry, Cheminformatics or a related discipline 5+ years of industry experience, or 3+ years in industry plus 2+ years academic post-doc experience Solid working knowledge of drug discovery principles including the fundamentals of medicinal chemistry, assay technology, structural biology and disease biology Strong communication skills and ability in formulating clear scientific hypothesis as well as articulating them during constructive dialogues with multi-disciplinary teams. Track record of scientific contributions in the areas of CADD illustrated by publications and/or patents. Appetite for molecular design fostered by a sound understanding of 3D modeling concepts (protein-ligand interactions, small molecule conformations, …) Experience in AI/ML approaches including model building and statistical analysis Familiarity with at least one programming language (Python, R, C, C++ …) Proficient with three or more of the modeling and data analysis/visualization software such as Schrodinger, MOE, OpenEye Suite, Pipeline Pilot, Knime, Spotfire, D360 Experience in (or some of them) compound generative model, data mining and visualization, chemical space analysis (clustering, compound library assessment and HTS data triage), active-learning based virtual screening, free energy calculation, quantum mechanics calculation, or other novel computational approaches Fluency in written and spoken English is mandatory-
Senior Scientist, Drug Discovery Expert
3 weeks ago
Shanghai, Shanghai, China Roche Full timeJob SummaryWe are seeking a highly skilled Senior Scientist to join our team at the China Innovation Center of Roche (CICoR). This role will involve collaborating with research scientists and data experts on drug projects from target identification to lead discovery and early development.About the PositionThe ideal candidate will have a Ph.D. in...
-
Advanced AI Researcher in Drug Development
3 weeks ago
Shanghai, Shanghai, China Roche Full timeAbout the RoleWe are seeking a highly skilled AI researcher to join our team at Roche, focusing on drug development. In this role, you will collaborate with computational biologists and chemists to develop AI algorithms, build models, and implement solutions for drug research and development.Key ResponsibilitiesYou will contribute significantly to our AI...
-
AI Researcher and Data Scientist
1 month ago
Shanghai, Shanghai, China Roche Full timeKey Responsibilities:You will be a key individual contributor to our AI strategy and the AI pillar of the AIDD team to increase the success rate of drug portfolio projects and the productivity of R&D.You will identify, develop, and implement appropriate AI solutions to generate scientific insights, target identification, molecule design, and prediction,...
-
Research Scientist
4 weeks ago
Shanghai, Shanghai, China Roche Full timeCompany OverviewRoches mission is to improve human life by unlocking the full potential of healthcare.About RocheRoche is a leading research-focused healthcare group involved in the development, production, and distribution of pharmaceuticals and diagnostic laboratory systems. Our innovative medicines and diagnostic tests help patients with serious diseases...
-
Shanghai, China Roche Full timeThe Position Primary Purpose of Job Collaborate with a group of immunology scientists and associates to provide expert biology support to preclinical and clinical studies for the discovery and development of new therapeutic agents. Scientists are responsible for contributing to new medical hypothesis, new target validation, new project initiation and...
-
Senior Researcher in Computational Chemistry
1 month ago
Shanghai, Shanghai, China Roche Full timeJob SummaryAs a member of the AI, Data and Digital (AIDD) team, you will partner with research scientists and data experts at China Innovation Center of Roche (CICoR) to advance drug projects from target identification to lead discovery and early development. Your expertise in computational chemistry and cheminformatics skills will be employed to provide...
-
Scientist, AI Researcher
6 months ago
Shanghai, China Roche Full timeThe Position Primary Purpose of Job We are seeking a talented artificial intelligent (AI) researcher to join AI, Data and Digital (AIDD) team at China Innovation Center of Roche (CICoR). In this role, you will collaborate with computational biologists and chemists, as well as informatics and digital experts to develop AI algorithms, build...
-
Shanghai, Shanghai, China Roche Full timeJob SummaryThe position of Formulation Scientist/Senior Scientist/Principal Scientist is responsible for conducting preformulation and formulation research to support Roche China (CICoR) portfolio assets and technical development. As a resident preformulation expert, the successful candidate will optimize the in-house capability to create innovative and...
-
Senior Computational Engineer
3 weeks ago
Shanghai, Shanghai, China Carrier Full timeWe are seeking a highly skilled Senior Computational Engineer to join our team at Carrier. This is an exciting opportunity to leverage your expertise in scientific computing and DevOps principles to drive innovation and efficiency in our engineering practices.Job SummaryThe successful candidate will provide technical leadership in the area of computational...
-
Shanghai, Shanghai, China Roche Full timeThe RoleThis is a key position for a medical lead or principle/senior clinical scientist at the Early Development department of the China Innovation Center of Roche.Key responsibilities include providing medical/clinical expertise in the early clinical development strategy, driving clinical study design, progress, clinical data review and interpretation, and...
-
AI Researcher
2 months ago
Shanghai, Shanghai, China Roche Full timeJob Title: Scientist, AI ResearcherWe are seeking a talented artificial intelligent (AI) researcher to join the AI, Data and Digital (AIDD) team at China Innovation Center of Roche (CICoR). In this role, you will collaborate with computational biologists and chemists, as well as informatics and digital experts to develop AI algorithms, build fit-for-purpose...
-
Shanghai, Shanghai, China Cadence Design Systems, Inc. Full timeCadence Design Systems, Inc. is seeking a Senior Sales Executive to join our team in Beijing/Shanghai.Cadence CFD offers a combination of state-of-the-art solutions encompassing multi-physics, combined with a robust geometry to results process in an environment that leverages Design Optimization and Machine Learning.In this role, you will work closely with...
-
Immunology Research Scientist
1 month ago
Shanghai, Shanghai, China Roche Full timeJob SummaryAs a key member of our immunology team, you will collaborate with scientists and associates to provide expert biology support for preclinical and clinical studies. Your primary responsibility will be to contribute to new medical hypotheses, target validation, project initiation, and research plan execution. You will work closely with...
-
Senior Computational Engineer
6 months ago
Shanghai, China Carrier Full timeCountry: China Location: LOC3254: No.3239 Shenjiang Road, Shanghai, Pudong New Area, Shanghai, China 角色职责: As a Senior Computational Engineer, you provide technical expertise in the area of scientific computing and promote the best practice of DevOps and CI/CD. You engage with global product teams and work with modeling and...
-
Principal Scientist, China Clinical Pharmacology
6 months ago
Shanghai, China Roche Full timeThe Position Position: We are seeking a highly motivated, dynamic, and experienced leader to lead strategic Clinical Pharmacology support for the China development projects supported by the Clinical Pharmacology Department at Principal Scientist will develop, oversee and lead the strategy and execution of efforts to support the increasing portfolio...
-
Senior Data Scientist
4 weeks ago
Shanghai, China Bosch Group Full timeJob DescriptionWe are seeking a highly skilled and experienced Senior Data Scientist / AI Engineer to join our team. As a Senior Data Scientist / AI Engineer, you will be responsible for developing and implementing cutting-edge solutions using Python, Machine Learning, LLMs, and classical NLP methodologies. You will work closely with our team of experts to...
-
Senior Data Scientist
4 weeks ago
Shanghai, China Bosch Full timeJob Description We are seeking a highly skilled and experienced Senior Data Scientist / AI Engineer to join our team. As a Senior Data Scientist / AI Engineer, you will be responsible for developing and implementing cutting-edge solutions using Python, Machine Learning, LLMs, and classical NLP methodologies. You will work closely with our team of experts...
-
Oncology Medical Lead/Clinical Scientist
7 months ago
Shanghai, China Roche Full timeThe Position The medical lead or principle/senior clinical scientist at the Early Development (ED) department of the China Innovation Center of Roche (CICoR) is responsible for providing medical/clinical expertise in the early clinical development strategy of a CICoR governed global program, driving clinical study design, progress, clinical data review...
-
Computer Vision Research Scientist
1 month ago
Shanghai, Shanghai, China CTW Full timeJob SummaryWe are seeking a highly skilled Computer Vision Research Scientist to join our team at CTW. As a key member of our research team, you will be responsible for implementing cutting-edge computer vision technologies, such as GAN and Stable Diffusion, to enhance our in-house banner generation tool.Main ResponsibilitiesLeverage computer vision...
-
Senior Data Scientist Leader
3 weeks ago
Shanghai, Shanghai, China IQVIA Full timeJob DescriptionAt IQVIA, we are seeking a highly skilled Senior Data Scientist to lead our Healthcare Analytics team. This is a unique opportunity to leverage your technical expertise and business acumen to drive strategic growth and innovation in the life sciences industry.About the RoleWe are looking for a seasoned data scientist with experience in...
